Here, though we haven’t directly assessed how M-MDSC accumulation is more profound but it could be envisaged that altered hematopoiesis might results in a considerable expansion and accumulation of immature myeloid cells (IMCs) in the tumor microenvironment (TME), in secondary lymphoid organs and tissues, driven by tumor-derived growth factors and other soluble factors via STAT1, STAT3, STAT6, COX2 or the NF-κB pathway (29). This evidence concerns the gene STAT3 and neoplasm.