Since other studies demonstrated that DNA damage induction with chemotherapy and RT (12) stimulates the STING pathway and the immune response, the present study used preclinical SCLC cell models to show a significant positive modulation of innate immune pathway genes (STING and MAVS) accompanied by increased DNA damage with sequential chemotherapy and RT treatment in vitro. The gene discussed is STING1; the disease is small cell lung carcinoma.