TRIM5 has been reported as a prognostic factor for hepatocellular carcinoma and glioma, which may affect the immune and inflammatory response of virus-infected cells by promoting Lys-63 ubiquitination of MAP3K7/TAK1 complex, but the exact role of TRIM5 in tumors has not been reported (13, 14). Here, TRIM5 is linked to central nervous system cancer.