Our previous cytokine and chemokine profiling in short term cultures of dissociated YUMM3.3 melanoma grafts showed that Activin-A secretion by the cancer cells diminishes both the levels of IFN-γ and the secretion of CXCL9 and CXCL10 in the conditioned medium (17). The gene discussed is CXCL10; the disease is melanoma.