BRCA1 and neoplasm: Furthermore, cancer cell-intrinsic STING signaling associated with an inflamed cell state has been shown to facilitate metastatic growth in preclinical models of breast cancer by activating NFκB (77), and it also mediates tumor immune evasion and immunotherapy resistance in genetically unstable BRCA1 mutant ovarian cancer by driving VEGFA-induced tumor vascularization (78).