SIRT1 and vitiligo: Our group investigated SIRT1 signaling in perilesional skin biopsies from 16 non-segmental vitiligo patients and found that SIRT1 activation may protect perilesional keratinocytes from damage by downregulating pro-apoptotic molecules [e.g., Jun N-terminal kinase (JNK1) and p38 kinases] and decreasing oxidative stress (Becatti et al., 2014a).