Notably, PEX14 has been identified as a key risk factor in triple-negative breast cancer (TNBC) (Purrington et al., 2014) and is one of the top five genes influencing adaptive anti-tumor immunity, as shown in a TNBC model study using a whole-genome RNAi screening platform (Shuptrine et al., 2017). The gene discussed is PEX14; the disease is triple-negative breast carcinoma.