HMGA2 protein can be delivered to endothelial cells, disrupting the integrity of endothelial junctions, thereby increasing vascular permeability, disrupting vascular barriers, and achieving distant metastasis of tumors (39)high expression of HMGA2 can promote the expression of interstitial markers such as Vimentin and decrease the expression of epithelial markers such as E-cadherin, thereby increasing the chance of invasion and metastasis of malignant tumors (55). The gene discussed is HMGA2; the disease is cancer.