Kaempferol (11) causes apoptosis and arrests the murine melanoma B16 cells (Qiang et al., 2021) and acts through different pathways such as epidermal growth factor receptor/mitogen-activated protein kinas/a serine/threonine protein kinase (EGFR/MAPK/AKT) pathways in human cervical cells (Tu et al., 2016) and blocked EGFR-related pathways in pancreatic cancer (Lee and Kim, 2016). Here, AKT1 is linked to melanoma.