Withaferin A (19), the main withanolide in W. somnifera, modulated TGF-β (Transforming growth factor-β) signaling in endometrial cancer (Xu et al., 2021) and suppressed STAT3 (signal transducer and activator of transcription 3) in multiple myeloma and neuroblastoma (Yco et al., 2014). The gene discussed is STAT3; the disease is plasma cell myeloma.