TGFB1 and AL amyloidosis: Withaferin A (19), the main withanolide in W. somnifera, modulated TGF-β (Transforming growth factor-β) signaling in endometrial cancer (Xu et al., 2021) and suppressed STAT3 (signal transducer and activator of transcription 3) in multiple myeloma and neuroblastoma (Yco et al., 2014).