CD8A and neoplasm: However, in the tumor-bearing mice treated with PLX3397 and paclitaxel, there was a positive immune modulation, and the proportion of M2 macrophages, MDSCs, neutrophils, and inflammatory monocytes in the ascites TME was reduced, while the CD8+ T cell proportion was increased, suggesting that the combination treatment not only reduced the suppression of natural immunity but also enhanced the function of the acquired immunity.