M-HNPs coated interleukin-10 (IL-10) mRNA, mediated by mannose receptor (CD206), targeted IL-10 mRNA delivery to the site of atherosclerotic lesions and translated into anti-inflammatory factor IL-10, which increased the thickness of fiber cap by decreasing the accumulation of lipids and the size of necrotic areas, thus promoting inflammation regression, inhibiting oxidative stress and apoptosis and played an anti-atherosclerosis role. The gene discussed is IL10; the disease is atherosclerosis.