The main pathways involved in the pathogenesis of hepatocellular carcinoma (HCC) include Hedgehog, vascular endothelial growth factor (VEGF), hepatocyte growth factor/c-MET, WNT/b-catenin, mitogen-activated protein kinase (MAPK)/ERK, as well as PI3K/AKT/mTOR.1 Here, HGF is linked to hepatocellular carcinoma.