To further validate the role and precise mechanism of hepatic DDX17 in the development of NASH, we subjected DDX17‐Flox and DDX17‐CKO mice to a MCD diet for 16 weeks, which were respectively labelled as Flox‐MCD and CKO‐MCD mice for short. Here, DDX17 is linked to metabolic dysfunction-associated steatohepatitis.