Given that impaired blood flow induced by sequestration of iRBCs on lung postcapillary venules was commonly observed in lung tissue of malaria patients with ALI and experimental MA-ALI mice, these findings raise an intriguing possibility that Piezo1 in macrophages could mediate the severity of MA-ALI by sensing impaired pulmonary blood flow. Here, PIEZO1 is linked to acute respiratory distress syndrome.