Although the exclusive mechanism underlying Piezo1 mediates macrophage functions (e.g. M1/M2 polarization, apoptosis and ferroptosis) and its potential role in severity of MA-ALI requires further investigation, our findings suggest that inhibition of Piezo1 channel in macrophages could be a potential therapeutic target for treating MA-ALI. The gene discussed is PIEZO1; the disease is microtia.