This study has several limitations: (i) Our limited facilities did not allow us to directly determine the change in pulmonary blood flow during P. berghei ANKA infection and identify the link between the activity of Piezo1 and change in pulmonary blood flow; (ii) Piezo1-depleted or KO mice were not suited to exploring the function of Piezo1 in the severity of MA-ALI; (iii) the present study did not accurately elucidate how Piezo1 exclusively targeted macrophage ferroptosis or M1/M2 polarization in the process of MA-ALI. Here, PIEZO1 is linked to acute respiratory distress syndrome.