PIEZO1 and malaria: It was reported that pulmonary mechanical status changes (e.g. impaired blood flow) were primarily triggered by sequestrations of iRBCs on lung postcapillary venules in both malaria patients with ALI and a murine model of MA-ALI [7], indicating that Piezo1 may be involved in the pathogenic process of MA-ALI via sensing impaired pulmonary blood flow.