Qi et al. [111] identified a class of SPP1+ TAMs in colorectal cancer, expressing high levels of SPP1 and the scavenger receptor MARCO. These macrophages promoted the proliferation of extracellular matrix by interacting with FAP+ CAFs via TGFB1, thereby inhibiting the infiltration of T cells within the tumor. This evidence concerns the gene TGFB1 and neoplasm.