Respectively, parallel to several previous studies, it was reported that hyperthyroidism impaired the Nrf2/Keap-1 pathway [49, 60] leading to a time-dependent elevation in the total mRNA expression of Nrf2 in the liver and its subsequent downstream antioxidant (GSH) as an early cytoprotective response to attenuate the oxidative stress damage and restore redox homeostasis [61]. The gene discussed is KEAP1; the disease is hyperthyroidism.