Additionally, it was found that Nrf2 activation alleviates hepatic fibrosis by modulating the antioxidant stress response and thus diminished DNA damage, hindering the inflammation triggered by the pro-fibrotic macrophage besides preventing activation of the HSCs by TGF-β1/Smad pathway confirming the anti-fibrotic potential of the Nrf2 [79]. This evidence concerns the gene NFE2L2 and Hepatic fibrosis.