Respectively, parallel to several previous studies, it was reported that hyperthyroidism impaired the Nrf2/Keap-1 pathway [49, 60] leading to a time-dependent elevation in the total mRNA expression of Nrf2 in the liver and its subsequent downstream antioxidant (GSH) as an early cytoprotective response to attenuate the oxidative stress damage and restore redox homeostasis [61]. Here, NFE2L2 is linked to hyperthyroidism.