From the results of KEGG analysis, the top enriched pathways included ‘Pathways in cancer’, ‘Lipid and atherosclerosis’, ‘PI3K-Akt signaling pathway’, ‘Human cytomegalovirus infection’, ‘Kaposi sarcoma-associated herpesvirus infection’, ‘Hepatitis B’, ‘Hepatitis B’, ‘Proteoglycans in cancer’, ‘AGE-RAGE signaling pathway in diabetic complications’, ‘Prostate cancer’, ‘MAPK signaling pathway’, ‘Cellular senescence’ and so on, suggesting that the enriched pathways from KEGG are likely to be related to the anticancer mechanism of SH003 in NSCLC. This evidence concerns the gene RENBP and Herpesviridae infectious disease.