METTL16 and hepatocellular carcinoma: METTL16 KO dramatically suppressed the growth of HCC cells (Additional file 1: Fig. S2H–K), which could be completely rescued by overexpression of wild-type (WT) METTL16 (sgRNA-resistant), demonstrating the high specificity of our sgRNA (Additional file 1: Fig. S2L–N).