Despite multiple members in human METTL family have been characterized as m6A methyltransferases [24, 56, 69], METTL16 is the most essential one for the survival of cancer cells, which might be attributed to its methyltransferase activity-dependent and -independent functions and especially its pivotal role in protein synthesis, including rRNA processing, ribosome biogenesis and translation initiation. The gene discussed is METTL16; the disease is cancer.