METTL16 and neoplasm: More interestingly, we collected the protein samples from HDTVi-HCC tumors and their adjacent normal liver tissues (Fig. 1R) and found that Mettl16 abundance is much higher in HDTVi-HCC tumors than normal liver tissues (Fig. 1S and Additional file 1: Fig. S1H), reiterating the tumor-promoting role of Mettl16 in de novo hepatocarcinogenesis.