To evaluate the role of Mettl16 in HCC development and normal hepatogenesis, we created liver-specific Mettl16 conditional KO (cKO) mice (Mettl16fl/fl-Alb-Cre) through crossing our recently generated Mettl16fl/fl mice [44] with Albumin-Cre mice (Fig. 1B). The gene discussed is METTL16; the disease is hepatocellular carcinoma.