METTL16 and hepatocellular carcinoma: To define whether the distribution of METTL16 in the nucleolus is related to HCC pathogenesis, we first compared nucleolar structural characteristics between non-malignant normal cells (CL-48, THLE-2, and HEK293T) and HCC cells (SUN449, HepG2, Huh7, Hep3B, and PCL/PRF/5).