Surprisingly, our results also found that the decreased expression of miR-30a-5p in exosomes caused by BSHLD was accompanied by decreased levels of GCs autophagy and NLRP3-mediated pyroptosis, as evidenced by reducing NLRP3, caspase-3, ASC, IL-1β and IL-18 levels, whiles these changes were all markedly reversed after miR-30a-5p overexpression, which implied that exosomal miR-30a-5p might be one of the markers of disease progression of PCOS. The gene discussed is CASP3; the disease is polycystic ovary syndrome.