SIRT1 and colorectal carcinoma: Marked mitochondrial fragmentation is observed when SIRT3 and SIRT1 are deficient or inhibited in CRC cells, accompanied by ROS overproduction, decreased MMP, open mitochondrial permeability transition pore (mPTP), upregulated fission indicators, and decreased fusion indicators, ultimately inducing abnormal mitochondrial division and CRC apoptosis [51, 52].