ADP-ribosylation factor 1(ARF1) expression is linked to poor survival in CRC and activates ERK signaling by enhancing the interaction of IQ-domain GTPase-activating protein 1 (IQGAP1) with ERK and MEK, promoting mitochondrial division and colon tumorigenesis [35]. The gene discussed is MAP2K7; the disease is colorectal carcinoma.