IGHE and allergic asthma: Further supporting evidence came from the study by Schmit using an allergic asthma murine model, in which IL-6-deficient mice were characterized by increased infiltration of immune cells, fewer goblet cells, more subepithelial fibrosis around large and distal airways, and an increased number of lung eosinophils compared with that in wild-type asthmatic mice, whereas they did not exhibit any differences in the serum levels of IgE or B- and T-cell frequencies in the lung [35].