INS and obesity due to melanocortin 4 receptor deficiency: The association between MSAB and risk of T2D become non-significant only among the participants in the lowest quartile of lipodystrophy (HR=1.06, 95%CI:0.99-1.14), and such association was still significant among participants in the lowest quartile of other PRS (HR=1.12, 95%CI:1.05-1.19 for T2D-PRS; HR=1.13, 95%CI:1.06-1.21 for HbA1c deposition; HR=1.09, 95%CI:1.02-1.17 for β-cell function; HR=1.13, 95%CI: 1.06-1.20 for obesity; HR=1.10, 95%CI:1.03-1.17 for proinsulin synthesis; HR=1.13, 95%CI:1.07-1.21 for liver function).