The third objective of this analysis is to identify potential parallel trends between excess-free-fructose intake trends and the “unexplained” US childhood asthma epidemic – “a disease condition linked to unpaired fructose induced gut dysbiosis [17–22] and the gut/lung axis [23–25];” and to elevated receptor of advanced glycation end-product (RAGE) signaling [51, 52]. This evidence concerns the gene AGER and childhood onset asthma.