CHRNB2 is a crucial component of the nicotinic acetylcholine receptor and is connected to nicotine dependence, epilepsy, and cancer patient metastasis [55, 56].The gene FBXL17 encodes a little-studied member of the F-box family of proteins, which are essential for the ubiquitin conjugation pathway and control important cellular functions like cell cycle progression, cell signaling, and receptor recycling. This evidence concerns the gene CHRNB2 and cancer.