FBXL17 and nicotine dependence: CHRNB2 is a crucial component of the nicotinic acetylcholine receptor and is connected to nicotine dependence, epilepsy, and cancer patient metastasis [55, 56].The gene FBXL17 encodes a little-studied member of the F-box family of proteins, which are essential for the ubiquitin conjugation pathway and control important cellular functions like cell cycle progression, cell signaling, and receptor recycling.