IVW-MR analysis also found evidence for the casual association between MTOR, ARNTL, KRAS, and RPSA with UC along with arthropathy ((OR 0.334, 95%CI 0.239–0.467; OR 0.607, 95%CI 0.499–0.739; OR 1.537, 95%CI 1.927–1.980; OR 1.756, 95%CI 1.133–2.724, respectively) (Fig. 3, Supplementary Table 3). Here, RPSA is linked to arthropathy.