In SMR analysis of circadian clock genome-wide cis-eQTLs and UC with arthropathy (Fig. 2, Supplementary Table 2), results found suggestive evidence for the association of the increased expression of MTOR, ARNTL, USP7, and RPSA in blood with the lower risk of UC with arthropathy (OR 0.343, 95%CI 0.155–0.759; OR 0.581, 95%CI 0.380–0.890; OR 0.036, 95%CI 0.002–0.843; OR 0.261, 95%CI 0.079–0.857, respectively). The gene discussed is CLOCK; the disease is arthropathy.