The hypomethylated DMRs observed in alcoholic cirrhosis and alcoholic HCC were found in ZBTB38, sulfotransferase family 2B member 1 (SULT2B1), FMN1, aldehyde dehydrogenase 3 family member B2 (ALDH3B2), solute carrier family 6 member 19 (SLC6A19), kazrin, periplakin interacting protein (KAZN), long intergenic non-protein coding RNA 1550 (LINC01550), potassium voltage-gated channel subfamily Q member 1 (KCNQ1), troponin T3, fast skeletal type (TNNT3), PNKD metallo-beta-lactamase domain containing (PNKD), E74 like ETS transcription factor 1 (ELF1), and tropomyosin 4 (TPM4) genes. The gene discussed is KAZN; the disease is alcoholic liver cirrhosis.