Compared with normal group, the expression levels of BNIPL and KRT4 were downregulated, while IGFBP3, MMP10, MMP3, and TGFBI were upregulated in LC tissues, which were same as the analysis results in the GEO datasets (Fig. 7A-F). Here, IGFBP3 is linked to laryngotracheoesophageal cleft.