After adjust for sex, GA, BW, maternal fever, placenta previa, antenatal antibiotic use, PROM, pregnancy hypertension, gestational diabetes, ICP, antenatal steroids, maternal autoimmune diseases and delivery mode, the incidence of CRP ≥ 8 mg/L in MAS was 2.89 times compared without MAS (OR 2.89, 95%CI: 0.90–9.26, P = 0.073), which indicated MAS had a positive correlation on CRP but in this research, it may be limited by the sample size. The gene discussed is CRP; the disease is meconium aspiration syndrome.