These include tumour‐borne factors like leukaemia inhibitory factor (LIF),S4 zink‐alpha glycoprotein (ZAG),S5 tumour necrosis factor alpha (TNFα)S6 or growth differentiation factor 15 (GDF‐15).S7 Beta‐blocker,S8 anabolic and orexigenic agents like enobosarmS9 or anamorelinS10 have been proven valuable to ameliorate weight loss in mouse models of CAC and in off‐label clinical use.15 This evidence concerns the gene AZGP1 and neoplasm.