Evaluation of the autoimmune status of all patients showed no significant differences among the thymoma, TMGH and TMGL groups in PB concentrations of IgG, IgA, IgM, IgE, C3, C4, CRP, ALB, α1-globulin, α1-globulin, α2-globulin, β1-globulin, β2-globulin, γ-globulin, A/G and ANA antibodies. This evidence concerns the gene C4A and thymoma.