Purroy et al.10 and Wunderlich et al.21 correlated NSE levels with the size of stroke based on diffusion-weighted imaging (DWI) and CT scans, respectively, within a week of the stroke onset (p = 0.00, Spearman’s coefficient = 0.191 and p = 0.005, r2 = 0.15, respectively). The gene discussed is ENO2; the disease is stroke disorder.