Furthermore, changes in CHGB neuropeptides in the SZ iNs are noteworthy because CHGB neuropeptide forms are dysregulated in human Alzheimer’s disease (AD) brains with severe cognitive deficits [46], and CHGB neuropeptides accumulate in amyloid plaques of human AD brains [47, 48]. Here, CHGB is linked to Cognitive impairment.