Moreover, the relevance of the miRNA signature is supported by multiscale correlations between macroscopic, clinical, and miRNA parameters, some of which had previously been described, such as CRP levels positively correlated with high grades of skin radiation injuries following radiotherapy in breast cancer patients45, or miR-146a-5p expression negatively correlated with CRP levels in patients with dermatomyositis46. This evidence concerns the gene CRP and breast carcinoma.