To understand whether the promotive effects incurred by NcDase abrogation are dependent on crosstalk between macrophages and T cells, we compared the tumor growth in Rag1−/− mice and Rag1−/−NcDase−/−mice upon the transfer of CD8+ T cells isolated from WT mice (designated as Rag1−/− CD8WT and Rag1−/−NcDase−/− CD8WT, respectively) or CD8+ T cells isolated from NcDase−/− mice (designated as Rag1−/− CD8NCKO and Rag1−/−NcDase−/−CD8NCKO, respectively). This evidence concerns the gene RAG1 and neoplasm.