ASAH2 and neoplasm: Using the lipophilic fluorescent dye BODIPY 493/503, we observed an increase of lipid droplets in F4/80+ macrophages in tumor tissue sections (Fig. 5c) and in isolated CD11b+ F4/80+ macrophages (Fig. 5c, d) from tumor tissue of NcDase−/− PyMT mice compared with those from WT PyMT mice.