Of note, when Ly6C expression was paired with CD39 expression, CyTOF profiling revealed that among CD8+ tumor infiltrating T lymphocytes (TIL), CD8+Ly6C+CD39- cells (CD8+ T1) were decreased to the greatest extent in the tumors from NcDase−/− PyMT versus WT PyMT mice. Here, CD8A is linked to neoplasm.