Most of the colocalizations of MHCII+ M1-like macrophages with CD8+ T cells in WT PyMT mice were in the tumor core, whereas colocalizations of CD206+ M2-like macrophages with CD8+ T cells in NcDase−/− PyMT mice were largely located in the tumor margin (Fig. 3a, b). This evidence concerns the gene CD8A and neoplasm.