ALYREF and cancer: These included components of the exon junction complex (such as Ayref, Pinin, Rnps1, and Ddx39b), transcription export complex (such as Alyref, Thoc1, and Thoc3), and the major mRNA exporter Nxf1. We note that these findings are in accordance with a recent study showing that XPO1 transports THOC4-bound mRNAs that encode for DNA damage repair proteins75, which in turn help protect cancer cells from MYC-induced DNA damage76,77.