At a result, we screened 148 proteins and 797 proteins significantly and stably overexpressed in the plasma samples and tumor tissues of CRC patients, respectively; among them, an overlapped 15 signatures (CPT1A, NUP205, CDC37, MAT2A, RPN1, GMPS, PSMA1, CDH1, SRSF7, FUBP3, PIGR, S100A8, S100A9, THBS2, and COL12A1) were elevated both in plasma and tissue samples of CRC patients. Here, RPN1 is linked to colorectal carcinoma.