Consistent with the enrichment results in the plasma proteome, we found that glycolysis and gluconeogenesis, adherens junction, TP53 transcriptional regulation, cellular response to chemical stress, and oncogenic MAPK signaling pathways were enriched in the tumor tissues; while immune regulation pathways such as complement system were enriched in the NATs (Supplementary Fig. 1H). This evidence concerns the gene TP53 and neoplasm.