Changes in the expression of RBPs such as QKI, RBM4, RBM5, RBM6, RBM10, and SRSF regulate many of the most common abnormal ASEs in lung cancer, as detailed by Coomer et al.252 Therefore, here we primarily summarize the significant research advancements in this field over the past 3–4 years. The gene discussed is QKI; the disease is lung cancer.