PTBP1 promotes annexin A7 (ANXA7) exon 6 inclusion, producing ANXA7-I2 isoform, which inhibits the degradation of receptor tyrosine kinase (RTK) epidermal growth factor receptor (EGFR) caused by endocytosis-dependent pathway degradation188 and leads to sustained activation of the EGFR signaling pathway.189,190 EGFR, PDGFRA, and MET proto-oncogene are observed in GBM cells with ANXA7-I2 highly expressed.191 It suggests that PTBP1 promotes the RTK signaling pathway sustained activation by regulating ANXA7 AS, inducing GBM angiogenesis, cell proliferation, and migration. This evidence concerns the gene ANXA7 and glioblastoma.