RBM3 and Familial prostate cancer: As a result, neuronal genes are expressed, leading to a loss of REST inhibitory activity.323 Importantly, bone metastasis is a common event among PCa patients.324 Recent findings suggest that the cold-stress response protein, RBM3, which is highly expressed in prostate cancer cells, can interfere with the ASE of CD44 to weaken Pca cell stemness.325 Under normal conditions, RBM3 upregulates m6A modification in CTNNB1 3’UTR, reducing the stability of catenin beta 1 (CTNNB1) mRNA, leading to a decrease in β-catenin protein levels and downregulation of Wnt signal transduction.