In addition, MYC in PDAC activates SRSF1354 to complete cytoplasmic-nuclear shuttling, regulating IL1R1 pre-mRNA 5’ UTR ASE in the nucleus to generate more stable mRNA isoforms and cause IL1R1 protein accumulation, which promotes the binding of IL1α/β secreted by epithelial cells and tumor matrix cells, feedback activates IL1 signal transduction355 and leads to activation of the MAPK pathway. The gene discussed is IL1R1; the disease is neoplasm.