CD44 and posterior cortical atrophy: The downregulation of RBM3 in PCa cells weakens this inhibitory effect.326 In addition to being regulated by RBM3, ASE of CD44 has also been reported to be regulated by PCBP1327 and TGF-β1.328 An increase in the expression of CD44 promotes EMT and upregulation of stem cell markers in PCa cells, thereby enhancing their invasive and tumorigenic abilities.