A systematical analysis of 83 cases of GC with normal mucosa matched, has classified GC into three subtypes based on ASEs: Epithelial Splicing (EpiS), Mesenchymal Splicing (MesS), and Mixed Splicing, with the crucial role of RBM24, RBMS1, and ESPR1 in the progression of GC underscored.269 This is the first study to propose a stratification scheme for GC patients based on ASEs, which holds significant potential for subsequent precision treatment. The gene discussed is RBMS1; the disease is gastric cancer.