APOB and metabolic dysfunction-associated steatohepatitis: Besides, SRSF3 is reported to be decreased in human liver samples with NAFLD, non-alcoholic steatohepatitis (NASH), or cirrhosis, leading to hepatic steatosis, fibrosis, and inflammation.431 In addition, HuR plays a key regulatory role in NAFLD by binding to Apob pre-mRNA intron 24, Uqcrb-3’UTR, and Ndufb6 mRNA 5’UTR, thereby regulating AS of Apob mRNA and UQCRB and NDUFB6 translation.