This leads to an increase in the expression of truncated forms of exon 7 downstream leucine-rich repeat Fli-1-interacting protein 2 (LRRFIP2), further regulating coactivator-associated arginine methyltransferase 1 (CARM1) histone methylation activity and leading to tumor metastasis.273 Besides, when HNRNPC binds with LINC00924, the binding of HNRNPC with Mnk2 pre-mRNA exon 14a is enhanced, thereby inhibiting the ASE of Mnk2a, and regulating the p38 MAPK/PPARα signaling pathway, further promoting tumor metastasis.274 PTBP3 is also upregulated in GC among patients with lymph node metastasis. This evidence concerns the gene MKNK2 and neoplasm.