ZMAT3 is a highly conserved RBP with tumor suppressor function.345 In CRC, p53, which has a high mutation frequency, has also been reported to regulate ZMAT3 to exert tumor suppressor function.346,347 Silencing ZMAT3 leads to the variant exon inclusion of CD44, increased expression of oncogenic long CD44 isoforms (CD44v), and silencing p53 results in the same outcome.348 In addition, an undefined RBP, Matrin3, was recently found to be involved in CDC14B ASEs. Here, ZMAT3 is linked to colorectal carcinoma.