This leads to an increase in the expression of truncated forms of exon 7 downstream leucine-rich repeat Fli-1-interacting protein 2 (LRRFIP2), further regulating coactivator-associated arginine methyltransferase 1 (CARM1) histone methylation activity and leading to tumor metastasis.273 Besides, when HNRNPC binds with LINC00924, the binding of HNRNPC with Mnk2 pre-mRNA exon 14a is enhanced, thereby inhibiting the ASE of Mnk2a, and regulating the p38 MAPK/PPARα signaling pathway, further promoting tumor metastasis.274 PTBP3 is also upregulated in GC among patients with lymph node metastasis. This evidence concerns the gene CARM1 and metastatic malignant neoplasm in the lymph nodes.