ESRPs, including ESRP1 and ESRP2, which are linked to cancer invasion, metastasis, and AS program regulation,139 significantly slow down the growth rate of ER + BRCA and alter EMT AS characteristics when ESRP1 is knocked out in vitro, as opposed to ESPR2.245 The knockout of ESRP1 in tamoxifen-resistant cells affects lipid metabolism and oxidoreductase processes, leading to a significant decrease in fatty acid synthase (FASN), stearoyl-CoA desaturase 1 (SCD1), and phosphoglycerate dehydrogenase (PHGDH) at both mRNA and protein levels. Here, PHGDH is linked to cancer.