Additionally, MBNL1 which is highly expressed in astrocytes, serves as a tissue-specific RNA metabolic regulator.214 It participates in transcriptional regulation by stabilizing, splicing, polyadenylating, and localizing target mRNA.215 MBNL1 pre-mRNA itself also undergoes AS,216 and its dysregulation will lead to many targeted genes undergoing ASEs from adult to fetal.217 MBNL1 is inhibited by hypoxia,218 promoting the maintenance of glioblastoma stem cells and immune evasion of GBM cells. The gene discussed is MBNL1; the disease is glioblastoma.