Frequent mutations in RBM10 result in the loss of its tumor suppression function, promoting tumor progression.259,260 RBM10 is involved in regulating the ASE of the mitochondrial apoptosis regulator Bcl-x, reducing the ratio of pro-apoptotic Bcl-xS to anti-apoptotic Bcl-xL. This evidence concerns the gene BCL2L1 and neoplasm.