This induces abnormal AS of EMT-related genes and activates Wnt signal transduction and MYC activity.374 The dephosphorylation of SRSF3 induced by PPM1G further regulates the cell cycle and transcription regulation-related gene ASEs to promote HCC progression.375 Besides, SRSF3 directly binds with the coiled-coil domain-containing 50 (CCDC50) pre-mRNA, inducing its ASE and maintaining its stability in the cytoplasm. Here, CCDC50 is linked to hepatocellular carcinoma.