The elimination of SRSF1 hinders the progression of gefitinib-resistant cancer cells by triggering autophagy.261 Besides, an important interaction pattern has been observed among AS-related RBPs, involving the non-classical activation of nuclear AURKA, which promotes the carcinogenic RNA splicing of tumor suppressor RBM4 under the guidance of m6A reader YTHDC1. This evidence concerns the gene SRSF1 and cancer.