In turn, the engagement of meta-inflammatory networks within fat depots impairs adipocyte liporegulatory capacities, inhibits energy-expenditure, including adaptive thermogenesis in brown adipose tissue (BAT) and white adipose tissue (WAT) browning, as well as propagates major obesity-associated sequelae, such as decreased sensitivity to insulin and ectopic lipid deposition [3, 4]. Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.