ACOD1 and Insulin resistance: Importantly, oral administration of itaconate (1 mM) to HFD-fed Acod1-/- mice was sufficient to rescue the levels of itaconate accumulation in the colon (Supplementary Fig. 2A) and to restore the effects of gene loss on body weight gain (Supplementary Fig. 2B), adiposity (Supplementary Fig. 2C) and insulin resistance (Supplementary Fig. 2D).