NFKB1 and neoplasm: Studies have shown that the M2 polarization of macrophages induced by CRC cell-derived exosomes containing miR-934 could be mediated by the CXCL13/CXCR5/NF-κB/p65 axis to promote colorectal cancer liver metastasis (CRLM), which led to crosstalk between tumour cells and TAMs, creating an inflammatory microenvironment for CRLM [116].