Researchers used a B16F10 mouse melanoma model to demonstrate that activated CD8+CD25+-Tregs can release exosomes, which expressed molecules related to lymphocyte function (IL-10 and TGF-β) to inhibit CTL antitumour immune responses, demonstrating that CD8+CD25+-Tregs-derived exosomes have significant immunosuppressive effects [80] (Fig. 1d). Here, CD8A is linked to melanoma.