MRC1 and colorectal carcinoma: Previous studies have reported FSTL3 is closely associated with macrophages in CRC [15, 16], and immunohistochemistry results showed that downregulation of FSTL3 suppressed the expression of F4/80, CD163, and CD206 in mouse tumors (Supplementary Fig. S6B), suggesting that FSTL3 promotes the infiltration and polarization of TAMs in CRC.