Furthermore, and importantly, we anticipate that VU0542270 or its optimized analogs will be useful for probing the therapeutic potential of vascular KATP channels in treating PDA, Cantu syndrome, migraine headache, and vascular collapse in sepsis without potentially confounding effects of inhibiting pancreatic and brain Kir6.2/SUR1 channels. The gene discussed is ABCC8; the disease is Headache.