PDCD4 and neoplasm: Another study in patients with gastrointestinal cancer reported that miR-196a2 represses three genes (ANXA1, DFFA, and PDCD4) that actively participate in apoptosis; however, it was remarked that in patients with CRC, deregulation of miR-196a2 and ANXA1 is associated with poor prognosis (advanced stages, high pathological grade, larger tumor size).4