VPS13B and Cohen syndrome: This gene encodes a protein that is important for non-vesicular lipid transport through intracellular membrane contact sites, and disorganizations in lipid constituents of organelle membranes would cause neurological disorders.46 Studies on flies also showed that VPS13B is necessary for the homeostasis of brain proteins.47Mutations in this gene would result in a well-characterized disorder, Cohen syndrome, with common clinical features, including ID, developmental delay, microcephaly, eye problems, and facial characteristics.48