Additionally, our team ensured the relationship between MRPS23 and mutation, alteration frequencies were 5.26%, 4.6%, 3.02%, and 2.19% in BRCA, pleural mesothelioma, endometrial cancer, BLCA, HNSC, and mature B-Cell neoplasms. The gene discussed is MRPS23; the disease is pleural mesothelioma.