In addition, our result indicated high MRPS23 expression correlated with poor OS for glioma, HNSC, KICH, LIHC, OSCC, and THCA, poor DSS in glioma, HNSC, KICH, KIRP, OSCC, and OV, and poor PFI in ACC, glioma, HNSC, KICH, KIRP, LIHC, and OSCC. This evidence concerns the gene MRPS23 and central nervous system cancer.