High MAEL expression was associated with few CD8+ T cells in tumor center (P=0.040), tumor margin (P=0.016), and total area (P=0.026), high TMB (P=0.013), and low expression of PDCD1 (P=0.003) and CTLA4 (P=0.049) rather than CD274 (P=0.12, Figure 5F). This evidence concerns the gene CTLA4 and neoplasm.