MAEL and chromophobe renal cell carcinoma: For instance, unlike pRCC and ccRCC originating from proximal tubular cells with high MAEL expression (Figure 1E), kidney chromophobe carcinoma (KICH) develops from distal tubular cells that did not express MAEL (Figure 1E) and had far lower expression of MAEL than KIRC and KIRP (Figure 2A).