AKT1 and nonpapillary renal cell carcinoma: Among the 16 ccRCC cell lines in the CCLE database, the IC50 values of VEGFR and PI3K-AKT-mTOR inhibitors were lower in those with high MAEL expression than those with low MAEL expression (above median; P<0.001, Figure 4F and Supplementary Table 9).