CD8A and neoplasm: Compared with the low MAEL expression group, the high MAEL expression group had more females (P=0.001) and the m1/4 cluster defined by the TCGA Research Network study (P<0.001) [47], lower CD8 densities in tumor center (P=0.044) and total area (P=0.040), higher TMB (P=0.028) and ITH (P=0.022), and lower expression of PDCD1 (P=0.010) and CTLA4 (P=0.038, Figure 5A).