ACE and hypertensive disorder: Previous studies have confirmed that acupuncture can arrest the development of hypertension in spontaneously hypertensive rats by regulating ACE, AT1R, and angiotensin II type 2 receptor (AT2R) [22, 23] and can improve quality of life by downregulating the ACE-AngII-AT1R axis and upregulating the ACE2-Ang (1–7)-MasR axis [24].