In contrast to what was previously described during acute infections, where the CD5hi CD4+ T cells predominated the response on day 8 post-infection [34], in the later stage of the anti-C. neoformans CD4+ T cell response in the lung, the CD5lo CD4+ T cells outnumbered CD5hi CD4+ T cells 4-fold (Fig 2H and 2I). Here, CD4 is linked to infection.