GRHL3 mutations lead to both syndromic (Van der Woude Syndrome, VWS; Peyrard-Janvid et al., 2014) and non-syndromic (Leslie et al., 2016) palatal clefts, and craniofacial defects are also seen in Grhl3−/− mice (Goldie et al., 2016; Peyrard-Janvid et al., 2014). This evidence concerns the gene GRHL3 and van der Woude syndrome.