Many studies reporting no association between TBI and AD neuropathologic changes, including CERAD score (55, 56), Thal phase (57), Braak stage (55–57), and AD pathologic diagnosis (55), while others reported higher amyloid-β load (34, 58), and some others (44, 58) reported higher PHF-tau tangles in those with TBI. This evidence concerns the gene MAPT and Alzheimer disease.