Cytoplasmic aggregation of TDP-43, accompanied by its nuclear clearance, is a common pathological hallmark of several neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), Alzheimer’s disease, and limbic-predominant age-related TDP-43 encephalopathy (LATE) (15–17). This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.