Analysis of consensus transcription factor binding sites associated with corin-induced transcriptomic changes in 451Lu-R and 1205Lu-R melanoma cells revealed significant increases in EMT-associated transcription factor motifs in both cell lines as well as increases in AP-1 transcription factor motifs (Figure 6E), supporting the specific relevance of corin effects on melanoma cell plasticity and phenotype switching. The gene discussed is JUN; the disease is melanoma.