As DUSPs are phosphatases that negatively regulate MAPK activity, we sought to further explore the functional significance of DUSP1 and DUSP5 as downstream effectors of corin with regard to the MAPK family members ERK, JNK, and p38 MAPK, which have all been implicated in melanoma resistance to targeted therapies (32, 35–37). This evidence concerns the gene MAPK8 and melanoma.