Indeed, corin-associated phenotypic changes in both MITFhi and AXLhi melanomas, including increased expression of E-cadherin and altered expression of MAPK, hedgehog signaling, focal adhesion, and axonal guidance–associated genes (Figure 5, C–E, Figure 6A, and Supplemental Figure 2, E and F), are reminiscent of those seen following inhibition of the neural crest differentiation–associated snail transcription factors during EMT in epithelial cancers (45). This evidence concerns the gene CDH1 and melanoma.