CORIN and melanoma: Indeed, corin-associated phenotypic changes in both MITFhi and AXLhi melanomas, including increased expression of E-cadherin and altered expression of MAPK, hedgehog signaling, focal adhesion, and axonal guidance–associated genes (Figure 5, C–E, Figure 6A, and Supplemental Figure 2, E and F), are reminiscent of those seen following inhibition of the neural crest differentiation–associated snail transcription factors during EMT in epithelial cancers (45).