Comparison of corin-associated RNA-Seq data with publicly available data sets (3, 24, 25) supported a phenotype switch signature following corin treatment in both 451Lu-R and 1205Lu-R cells; genes associated with the corin-induced phenotype switch included AXL, MITF, SOX10, WNT5A, PAX3, ZEB1, ZEB2, PGC1a, DUSP1, and DUSP5 (Figure 6A) and were significantly associated with the intermediate melanoma phenotype signature recently reported by Wouters et al. (26) (Figure 6B and Supplemental Figure 3D). The gene discussed is PPARGC1A; the disease is melanoma.