Interestingly, our previous data demonstrated strong growth inhibition by corin in all melanoma and leukemia cell lines tested (16); however, 50% of breast cancer cell lines and 70% of colon cancer cell lines evaluated also demonstrated strong growth inhibition by corin, suggesting that specific transcriptional programs, possibly relevant to a neural differentiation phenotype, may promote particular dependencies on CoREST-mediated cell growth. The gene discussed is CORIN; the disease is breast cancer.