Here, we determined that the CoREST repressor complex modulated the predominant MAPKi-resistant melanoma phenotypes including the differentiated/proliferative (MITFhi/AXLlo) and neural crest stem cell–like/invasive (MITFlo/AXLhi) states and that corin treatment of BRAFi-R melanomas promoted the emergence of intermediate, BRAFi-S phenotypes that are concordant with recently profiled intermediate melanoma phenotypes (26). This evidence concerns the gene RCOR1 and melanoma.