CORIN and melanoma: Remarkably, all tumor cell lines demonstrating an MITFhi/AXLlo melanoma phenotype showed decreased expression of MITF and increased expression of histone H3K4me2, a common readout of LSD1 inhibition (19, 20), and H3K9ac/K27ac marks following corin treatment, without significant effects on the MEK/ERK pathway (Figure 1A).