ZEB1 and melanoma: Not surprisingly, the HOMER Motif analysis of H3K27ac, H3K9ac, and H3K4me2 ChIP-Seq peaks gained in melanoma cells following corin treatment (Figure 7D) also demonstrated significantly (P < 0.0001) increased peaks for the EMT-associated transcription factors Snail1, Slug, ZEB1, andZEB2, consistent with a predominant effect on melanoma phenotypes.