Western blotting confirmed corin-associated increased expression of the dual-specificity phosphatases DUSP1 and DUSP5 in BRAFi-R cell lines (Figure 9A), which notably demonstrated significantly increased expression of DUSP1 and DUSP5 proteins following both corin and corin plus PLX4032 treatment of 1205Lu-R and 451Lu-R melanoma cells, and induction of DUSP transcripts by corin/corin plus PLX4032 was confirmed by RT-qPCR (Supplemental Figure 8A). This evidence concerns the gene DUSP5 and melanoma.