Corin treatment of 451Lu-R and 1205Lu-R melanoma cells also led to increased expression of type 1 and type 2 IFN response genes and repetitive elements (Supplemental Figure 5 and Supplemental Tables 3–6) and decreased expression of RNA-induced silencing complex (RISC) components (Supplemental Table 7), similar to previously reported changes associated with LSD1 ablation in tumor cells (27). The gene discussed is SGCG; the disease is melanoma.