Notably, extended corin treatment of all melanoma cell lines (72 hours) led to substantial) growth inhibition with IC50 values consistently in the submicromolar range (Figure 1F, Table 1, Supplemental Figure 1, A–C, and Supplemental Table 1; supplemental material available online with this article; https://doi.org/10.1172/JCI171063DS1). This evidence concerns the gene CORIN and melanoma.