Interestingly, we also found that PLX4032 enhanced the antiproliferative effects of corin treatment alone in both BRAFi-R MITFhi/AXLlo and MITFlo/AXLhi melanoma cells (Figure 3D), with synergy identified between PLX4032 and corin in MITFhi/AXLlo and MITFlo/AXLhi melanoma cells (combination index [CI] <1.0 [ref. 23]) (Figure 3E, Table 2, Supplemental Figure 1D, and Supplemental Table 2). The gene discussed is CORIN; the disease is melanoma.