In contrast, DUSP1 knockdown in human melanoma cells led to loss of PLX4032 sensitivity in BRAFi-S melanoma cells (Supplemental Figure 9, A–C), with associated activation of p38 MAPK in 1205Lu cells (Supplemental Figure 9D), further supporting a critical role for DUSP1 in mediating melanoma resistance to BRAFi treatment. Here, DUSP1 is linked to melanoma.