Of note, the dual-specificity phosphatases DUSP1 and DUSP5 were among the genes whose expression was most highly upregulated in the MAPK signaling GSEA and significantly (adjusted P [Padj] < 1 × 10–31 ) upregulated following corin treatment in both BRAFi-R cell lines (Figure 6C) as well as additional melanoma cell lines (Figure 6D). Here, DUSP1 is linked to melanoma.