Additionally, we explored the transcriptomic and epigenomic landscapes regulated by CoREST inhibition and found specific alteration of epithelial-mesenchymal transition–associated (EMT-associated) transcription factors following corin treatment of BRAFi-R melanomas in addition to upregulation of the dual-specificity phosphatases and downstream inhibition of p38 MAPK activity. Here, CORIN is linked to melanoma.