CORIN and melanoma: Moreover, treatment of melanoma cells for 24 hours with corin inhibited tumor cell growth in the majority of MITFhi/AXLlo melanoma cells evaluated; however, minimal growth inhibition and even enhanced cellular proliferation was seen in MITFlo/AXLhi cells following 24 hours of treatment with corin (Figure 1C), consistent with conversion of both distinctive melanoma cell line phenotypes to intermediate proliferation states following early corin treatment.