ZEB1 and melanoma: Indeed, a survey of melanoma cell lines using the Broad Institute’s DepMap portal (https://depmap.org/portal/) found statistically significant inverse dependencies of expression of MITF with SNAI1 and AXL with SNAI2 as well as a significant inverse relationship between SNAI1 and SNAI2 as well as ZEB1 and ZEB2 (Supplemental Figure 11, A–F).