Additionally, corin treatment with or without PLX4032 led to increased expression of H3K4Me2, H3K27Ac, DUSP1, and DUSP5 (Figure 12, A–C), as well as increased expression of markers of apoptosis and tumor hypoxia (Supplemental Figure 10) in BRAFi-R tumors, with associated decreases in the expression of both MITF and AXL (Figure 12C). Here, CORIN is linked to neoplasm.