Moreover, in a model of chronic cerebral hypoperfusion, which replicates the vascular contributions to cognitive impairment and dementia (VCID), the inhibition of astrocytic NHE1 resulted in the reduction of reactive astrocyte gliosis, preservation of white matter and hippocampal integrity, and enhancement of cognitive function by decreasing ROS production and inflammation [141]. This evidence concerns the gene SLC9A1 and Cognitive impairment.